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Article

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.

Molecular autism - 7 Mar 2025

Hooshmandi Mehdi, Ho-Tieng David, Lister Kevin C, Cai Weihua, Wong Calvin, Brown Nicole, Fan Jonathan, Hovhannisyan Volodya, Uttam Sonali, Prager-Khoutorsky Masha, Sonenberg Nahum, Gkogkas Christos G, Khoutorsky Arkady

Abstract excerpt

BACKGROUND: Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects. Microglia, immune cells critical for the refinement of neuronal circuits during brain development, have been implicated in various neurodevelopmental disorders, including fragile X syndrome. However, it is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40055803
DOI: 10.1186/s13229-025-00648-2
PMCID: PMC11887208

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