Article

DNA template heterogeneity and <i>in vitro</i> transcription reaction conditions impact the poly(A) tail length and heterogeneity of mRNA

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> mRNA technology has emerged as a powerful new class of medicines. Importantly, this RNA-based approach holds promise for treatments beyond vaccines and infectious diseases, including treatments for cancer, metabolic disorders, cardiovascular conditions and autoimmune diseases. The 3’-polyadenylated (poly(A)) tail of mRNA is required for ribosome initiation, translation, and mRNA stability and is...

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Literature Corpus work: 7734f453-4a6f-583b-bc11-9f2d5eb31fea
DOI: 10.64898/2026.07.02.735822

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