Article

Enhancement of synthetic mRNA translation efficiency through engineered poly(A) tails

2021-08-31

Abstract excerpt

<h4>SUMMARY</h4> In vitro transcribed (IVT) mRNA represents a new class of drug in both therapeutics and vaccines. Improving the translation efficiency of IVT mRNA remains a core challenge for mRNA-based applications. Here, using IVT mRNAs with poly(A) tails containing non-A residues which were recently revealed to be widespread in RNA poly(A) tails 1,2 , we unexpectedly find that non-A residues can effectively...

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Literature Corpus work: aa4615bf-44e7-5607-8814-a50aa93fb2d5
DOI: 10.1101/2021.08.30.458298

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