Article

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

2026-08-28

Abstract excerpt

Microglia are the predominant immune cells in multiple sclerosis (MS) demyelinating lesions, where they phagocytose myelin, but whether they destroy myelin or merely scavenge its debris is unknown. Here, we explore whether pathogenic autoantibodies found in MS may induce the phagocytic destruction of myelin by microglia. Applying patient-derived, myelin-targeting antibodies to the mouse cortex, we developed an in...

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Literature Corpus work: 2386904d-acea-560e-9a06-303425231ae8
DOI: 10.64898/2026.08.25.747169

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