Article

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

2019-11-15

Abstract excerpt

<h4>Summary</h4> Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes. Here, in striking similarity to other neurodegenerative diseases, we identify in postmortem human MS tissue and in nonhuman primate and mouse MS models profound synapse loss and microglial synaptic engulfment. These even...

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Literature Corpus work: c5819e0a-fe80-5eaa-8810-d68b4cd2c58b
DOI: 10.1101/841601

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