Article

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state

2024-12-11

Abstract excerpt

Aberrant and sustained activation of microglia is implicated in the progression and severity of multiple sclerosis (MS). However, whether intrinsic alterations in microglial function impact the pathogenesis of this disease remains unclear. We conducted transcriptomic and functional analyses of microglia-like cells (iMGLs) differentiated from induced pluripotent stem cells (iPSCs) from patients with MS (pwMS) to an...

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Literature Corpus work: 1cfd6f7f-44e0-5611-a963-772d6ef308eb
DOI: 10.1101/2024.12.10.627477

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