Article

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive Disease

2025-08-21

Abstract excerpt

<h4>Summary</h4> Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by increasing disability. The cellular and molecular drivers of clinical transition towards progressive disease are poorly understood. Here, we combine single-cell profiling technologies with genetic and pharmacological perturbations across the course of murine CNS inflammation to dissect t...

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Literature Corpus work: 1d0263b0-ac6d-5f0d-b3a7-d84443c618b7
DOI: 10.1101/2025.08.15.670462

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