Article
Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration
2020-09-04
Abstract excerpt
Meningeal inflammation strongly associates with demyelination and neuronal loss in the underlying cortex of progressive MS patients, contributing to clinical disability. However, the pathological mechanisms of meningeal inflammation-induced cortical pathology are still largely elusive. Using extensive analysis of human post-mortem tissue, we identified two distinct microglial phenotypes, termed MS1 and MS2, in the...
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Identifiers and source
- Literature Corpus work
- 13e8af9f-6435-5d44-a6b2-1a1224b5ad51
- DOI
- 10.1101/2020.09.03.281543