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Article

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.

Nucleic acids research - 5 May 2026

Li Jiayi, Petersen Kamilla Vandsø, Ummethum Henning, Bagge Jonas, Hinsby Emilie W, Lisby Michael, Nilsson Jakob, Oestergaard Vibe H

Abstract excerpt

TOPBP1 is a scaffold protein with multiple functions in genome integrity. During mitosis, TOPBP1 is coordinating DNA repair and genome maintenance, thereby reducing carry-over of DNA damage to daughter cells. This function emerges as a critical backup pathway in BRCA-deficient cells, yet many aspects of TOPBP1 regulation during mitosis remain unclear. Mitotic kinases are involved in regulating genome maintenance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42109249
DOI: 10.1093/nar/gkag462
PMCID: PMC13158665

Genes

TOPBP1
PLK1
BRCA2
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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TOPBP1-PLK1 interaction preserves genome integrity during mitosis.PMID 42109249Read ↗

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DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read ↗

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TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Semantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks.Semantic proximity Read ↗

Whole genome doubling confers unique genetic vulnerabilities on tumor cellsSemantic proximity Read ↗

Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-deficient Cancers: An UpdateSemantic proximity Read ↗

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Semantic proximity Read ↗

Polo-like kinases and DNA damage checkpoint: beyond the traditional mitotic functionsSemantic proximity Read ↗

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