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The CINs of Polo-Like Kinase 1 in Cancer

13 Oct 2020

Abstract excerpt

Polo-like kinase 1 (PLK1) is overexpressed near ubiquitously across all cancer types and dysregulation of this enzyme is closely tied to increased chromosomal instability and tumor heterogeneity. PLK1 is a mitotic kinase with a critical role in maintaining chromosomal integrity through its function in processes ranging from the mitotic checkpoint, centrosome biogenesis, bipolar spindle formation, chromosome...

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PMID: 33066048
DOI: 10.3390/cancers12102953

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