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A spatial atlas of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress

2024-08-06

Abstract excerpt

Mitochondrial genome expression is important for cellular bioenergetics. How mitochondrial RNA processing and translation are spatially organized across dynamic mitochondrial networks is not well understood. Here, we report that processed mitochondrial RNAs are consolidated with mitoribosome components into translation hubs distal to either nucleoids or processing granules in human cells. During stress, these hubs...

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Identifiers and source

Literature Corpus work
bc260ee8-dea7-5d2f-aa4a-ce8afba6c76f
DOI
10.1101/2024.08.05.604215
Open publication

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A spatial atlas of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stressDOI 10.1101/2024.08.05.604215
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