Article
Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology.
Cells - 19 Dec 2019
Kotrys Anna V, Szczesny Roman J
Abstract excerpt
Mitochondria are peculiar organelles whose proper function depends on the crosstalk between two genomes, mitochondrial and nuclear. The human mitochondrial genome (mtDNA) encodes only 13 proteins; nevertheless, its proper expression is essential for cellular homeostasis, as mtDNA-encoded proteins are constituents of mitochondrial respiratory complexes. In addition, mtDNA expression results in the production of...
Topics
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Humans
- Mitochondria
- Mitochondrial Proteins
- Transcription, Genetic