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Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes

9 Aug 2022

Abstract excerpt

BACKGROUND: Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To determine how human cells coordinate mitochondrial and nuclear gene expression processes, we tailored ribosome profiling for the unique features of the human mitoribosome....

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PMID: 35945592
DOI: 10.1186/s13059-022-02732-9

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