Article
High-resolution genomic analysis of human mitochondrial RNA sequence variation.
Science (New York, N.Y.) - 25 Apr 2014
Hodgkinson Alan, Idaghdour Youssef, Gbeha Elias, Grenier Jean-Christophe, Hip-Ki Elodie, Bruat Vanessa, Goulet Jean-Philippe, de Malliard Thibault, Awadalla Philip
Abstract excerpt
Mutations in the mitochondrial genome are associated with multiple diseases and biological processes; however, little is known about the extent of sequence variation in the mitochondrial transcriptome. By ultra-deeply sequencing mitochondrial RNA (>6000×) from the whole blood of ~1000 individuals from the CARTaGENE project, we identified remarkable levels of sequence variation within and across individuals, as...
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