Article

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease

2025-03-27

Abstract excerpt

<h4>Summary</h4> Mitochondrial endosymbiosis was a pivotal event in eukaryotic evolution, requiring core proteins to adapt to function both within the mitochondria and in the host cell. Here, we systematically profile the localization of protein isoforms generated by alternate start codon selection during translation. We identify hundreds of pairs of differentially-localized protein isoforms, many of which affect...

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Literature Corpus work: e80d718a-04c8-5acc-a1da-833859e53071
DOI: 10.1101/2025.03.27.645657

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