Article

Structure-Based Survey of the Human Proteome for Opportunities in Proximity Pharmacology

2022-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Proximity pharmacology (ProxPharm) is a novel paradigm in drug discovery where a small molecule brings two proteins in close proximity to elicit a signal, generally from one protein onto another. The potential of ProxPharm compounds as a new therapeutic modality is firmly established by proteolysis targeting chimeras (PROTACs) that bring an E3 ubiquitin ligase in proximity to a target protein to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac9774d8-1f19-55b0-a214-ec45bc3ceb29
DOI: 10.1101/2022.01.13.475779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure-Based Survey of the Human Proteome for Opportunities in Proximity PharmacologyDOI 10.1101/2022.01.13.475779Read

Expanding PROTACtable genome universe of E3 ligasesSemantic proximity Read

ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effectSemantic proximity Read

Targeted protein posttranslational modifications by chemically induced proximity for cancer therapySemantic proximity Read

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate RecognitionSemantic proximity Read

Targeting the Interplay of Proteins through PROTACs for the Management of Cancer and Associated DisordersSemantic proximity Read

GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular GluesSemantic proximity Read

Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACsSemantic proximity Read

A comprehensive primer and review of PROTACs and their In Silico designSemantic proximity Read

Proteolysis Targeting Chimeras With Reduced Off-targetsSemantic proximity Read

Identification of Suitable Target/E3 Ligase Pairs for PROTAC Development using a Rapamycin-induced Proximity Assay (RiPA)Semantic proximity Read

Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein DegradationSemantic proximity Read

PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat CancerSemantic proximity Read