Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

Abstract excerpt

We report an enantioselective protein affinity selection mass spectrometry screening approach (E-ASMS) that enables the detection of weak binders, informs on selectivity, and generates orthogonal confirmation of binding. After method development with control proteins, we screened 31 human proteins against a designed library of 8,210 chiral compounds. 16 binders to 12 targets, including many proteins predicted to b...

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• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA Research and Splicing
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

0e914e0b-802d-51d3-8136-735dff7a418d

DOI

10.1101/2025.01.17.633682