Article

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

2026-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Covalent chemistry coupled with activity-based protein profiling (ABPP) offers a versatile approach for small-molecule ligand discovery in native biological contexts. The covalent ligandability maps generated by ABPP that target cysteine have frequently leveraged the acrylamide as a reactive group due to its tempered electrophilicity and presence in many advanced tool compounds and therapeutics....

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Literature Corpus work: 826d720f-8c9d-51db-9177-695a43cf90f1
DOI: 10.64898/2026.02.21.707170

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