Article

Bivalent chromatin protects reversibly repressed genes from irreversible silencing

2020-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and H3K27me3, histone modifications generally associated with transcriptionally active and repressed chromatin, respectively. Prevalent in embryonic stem cells, bivalency is postulated to poise lineage-controlling developmental genes for rapid activation during embryogenesis while maintaining a transcriptionally represse...

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Literature Corpus work: 22e869f9-489b-5d99-b9d7-c671b7c77482
DOI: 10.1101/2020.12.02.406751

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