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Ancestral chromatin state constrains the functional landscape of bivalent domains in mammalian spermatogenesis

2026-04-16

Abstract excerpt

Mammalian germ cells are enriched for bivalent chromatin, an epigenetic state defined by the dual presence of the activating H3K4me3 and repressive H3K27me3 histone modifications. Bivalency is evolutionarily conserved at developmentally important genes in germ cells but diverges at hundreds of additional loci, and evolutionary gains in bivalency have been proposed to reflect divergent somatic functions of the asso...

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Literature Corpus work
4f7a1c42-ca90-52ce-ac6f-78b9833e0c8b
DOI
10.64898/2026.04.14.718508
Open publication

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Ancestral chromatin state constrains the functional landscape of bivalent domains in mammalian spermatogenesisDOI 10.64898/2026.04.14.718508
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