Article
Imprinting control regions (ICRs) are marked by mono-allelic bivalent chromatin when transcriptionally inactive.
Nucleic acids research - 29 Jan 2016
Maupetit-Méhouas Stéphanie, Montibus Bertille, Nury David, Tayama Chiharu, Wassef Michel, Kota Satya K, Fogli Anne, Cerqueira Campos Fabiana, Hata Kenichiro, Feil Robert, Margueron Raphael, Nakabayashi Kazuhiko, Court Franck, Arnaud Philippe
Abstract excerpt
Parental allele-specific expression of imprinted genes is mediated by imprinting control regions (ICRs) that are constitutively marked by DNA methylation imprints on the maternal or paternal allele. Mono-allelic DNA methylation is strictly required for the process of imprinting and has to be faithfully maintained during the entire life-span. While the regulation of DNA methylation itself is well understood, the...
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