Article

PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis

2024-12-23

Abstract excerpt

In most cancers, including endometrial cancer, tumor suppressor genes harboring inactivating mutations have been systematically cataloged. However, locus-specific epigenetic alterations contributing to cancer initiation and progression remain only partly described, creating knowledge gaps about functionally significant tumor suppressors and underlying mechanisms associated with their inactivation. Here, we show th...

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Literature Corpus work: ace58bfd-b99f-5f97-b330-9b4cf69ae7c8
DOI: 10.1101/2024.12.23.630121

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