Article

5-hydroxymethylcytosine profiling of cell-free DNA identifies bivalent genes that are prognostic of survival in high-risk neuroblastoma

2023-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Neuroblastoma is the most common extra-cranial solid tumor in childhood and epigenetic dysregulation is a key driver of this embryonal disease. In cell-free DNA from neuroblastoma patients with high-risk disease, we found increased 5-hydroxymethylcytosine (5-hmC) deposition on Polycomb Repressive Complex 2 (PRC2) target genes, a finding previously described in the context of bivalent genes. As b...

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Literature Corpus work: 2c8f4136-7e9c-531c-b0e6-c36a2e478af5
DOI: 10.1101/2023.04.27.538309

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