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Article

Functional Neurogenomics to Dissect Disease Mechanisms Across Models.

Annual review of genomics and human genetics - 1 Aug 2025

Zheng Xinhe, Li Jiwen, Jin Xin

Abstract excerpt

Tremendous progress has been made in identifying genetic variants associated with neurodevelopmental disorders (NDDs), particularly autism spectrum disorder (ASD). However, the extensive (and growing) lists of associated genetic variants have led to a bottleneck in understanding the function of these genetic changes. To overcome this, functional genomics approaches-including high-throughput and high-content...

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Identifiers

PMID: 40324921
DOI: 10.1146/annurev-genom-120823-125811
PMCID: PMC12782629

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