Article

Molecular cascades and cell-type specific signatures in ASD revealed by single cell genomics

2023-03-10

Abstract excerpt

Understanding how genetic variation exerts its effects on the human brain in health and disease has been greatly informed by functional genomic characterization. Studies over the last decade have demonstrated robust evidence of convergent transcriptional and epigenetic profiles in post-mortem cerebral cortex from individuals with Autism Spectrum Disorder (ASD). Here, we perform deep single nuclear (sn) RNAseq to e...

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Literature Corpus work: 01c989ae-63a7-56e6-aed2-0896d3314cb9
DOI: 10.1101/2023.03.10.530869

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