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Article

Molecular cascades and cell type-specific signatures in ASD revealed by single-cell genomics.

Science (New York, N.Y.) - 24 May 2024

Wamsley Brie, Bicks Lucy, Cheng Yuyan, Kawaguchi Riki, Quintero Diana, Margolis Michael, Grundman Jennifer, Liu Jianyin, Xiao Shaohua, Hawken Natalie, Mazariegos Samantha, Geschwind Daniel H

Abstract excerpt

Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood. We performed deep single-nucleus RNA sequencing (snRNA-seq) to examine cell composition and transcriptomics, identifying dysregulation of cell type-specific gene regulatory...

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Identifiers

PMID: 38781372
DOI: 10.1126/science.adh2602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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