Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.

doi:10.1038/s41586-022-05377-7

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Article

Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.

Nature - 1 Nov 2022

Gandal Michael J, Haney Jillian R, Wamsley Brie, Yap Chloe X, Parhami Sepideh, Emani Prashant S, Chang Nathan, Chen George T, Hoftman Gil D, de Alba Diego, Ramaswami Gokul, Hartl Christopher L, Bhattacharya Arjun, Luo Chongyuan, Jin Ting, Wang Daifeng, Kawaguchi Riki, Quintero Diana, Ou Jing, Wu Ye Emily, Parikshak Neelroop N, Swarup Vivek, Belgard T Grant, Gerstein Mark, Pasaniuc Bogdan, Geschwind Daniel H

Abstract excerpt

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by transcriptomic and epigenetic alterations1-3. In autism spectrum disorder (ASD), this molecular pathology involves the upregulation of microglial, astrocyte and neural-immune genes, the downregulation of synaptic genes, and attenuation of gene-expression...

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PMID: 36323788
DOI: 10.1038/s41586-022-05377-7
PMCID: PMC9668748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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