Article

Copy-number dosage regulates telomere maintenance and disease-associated pathways in neuroblastoma

2022-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Telomere maintenance in neuroblastoma is linked to poor outcome and caused by either TERT activation or through alternative lengthening of telomeres (ALT). In contrast to TERT activation, commonly caused by genomic rearrangements or MYCN amplification, ALT is less well understood. Alterations at the ATRX locus are key drivers of ALT but only present in ∼50% of ALT tumors. To identify potential n...

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Literature Corpus work: 227a37a1-7acd-50e6-bdd1-a97af67cebc2
DOI: 10.1101/2022.08.16.504100

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