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Article

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

24 Feb 2021

Abstract excerpt

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features using multi-omics profiling. ALT-positive tumors are molecularly distinct from other neuroblastoma subtypes and enriched in a population-based clinical sequencing...

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PMID: 33627664
DOI: 10.1038/s41467-021-21247-8

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