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Neuroblastoma and the epigenome

6 Jan 2021

Abstract excerpt

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the most common solid tumors in infancy. Amplification of MYCN, copy number alterations, numerical and segmental chromosomal aberrations, mutations, and rearrangements on a handful of genes, such as ALK, ATRX, TP53, RAS/MAPK pathway genes, and TERT, are attributed as underlying causes that give rise to NB. However, the...

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PMID: 33404859
DOI: 10.1007/s10555-020-09946-y

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