Article

Genomic footprints of activated telomere maintenance mechanisms in cancer

2017-06-30

Abstract excerpt

Cancers require telomere maintenance mechanisms for unlimited replicative potential. We dissected whole-genome sequencing data of over 2,500 matched tumor-control samples from 36 different tumor types to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXX trunc ) was increased, tumors with TERT modifications showed a moderate decr...

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Literature Corpus work: 6190398c-8bbd-58dc-aec3-8810d963f046
DOI: 10.1101/157560

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