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Article

Clinical Significance of TERT Promoter Mutations in Neuroblastoma.

JCO precision oncology - 1 Jul 2025

Persaud Natasha, Gundem Gunes, Kushner Brian H, Ladanyi Marc, Shukla Neerav, Modak Shakeel

Abstract excerpt

PURPOSE: Telomere maintenance mechanisms including MYCN amplification (MYCN-A) (via upregulated telomerase reverse transcriptase [TERT] expression), TERT rearrangements (TERT-RA), and ATRX mutations confer neoplastic immortality in neuroblastoma (NB) cells. Clinical characterization of patients with NB harboring activating somatic TERT promoter point mutations (TERT-PM) in NB may improve stratification. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40638875
DOI: 10.1200/PO-25-00074
PMCID: PMC12252578

Genes

TERT
MYCN
ATRX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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