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Article

Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma.

Genome biology - 4 Mar 2022

Sen Arko, Huo Yuchen, Elster Jennifer, Zage Peter E, McVicker Graham

Abstract excerpt

BACKGROUND: Neuroblastoma is a pediatric malignancy with a high frequency of metastatic disease at initial diagnosis. Neuroblastoma tumors have few recurrent protein-coding mutations but contain extensive somatic copy number alterations (SCNAs) suggesting that mutations that alter gene dosage are important drivers of tumorigenesis. Here, we analyze allele-specific expression in 96 high-risk neuroblastoma tumors...

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Identifiers

PMID: 35246212
DOI: 10.1186/s13059-022-02640-y
PMCID: PMC8896304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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