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Article

Genomic footprints of activated telomere maintenance mechanisms in cancer.

Nature communications - 5 Feb 2020

Sieverling Lina, Hong Chen, Koser Sandra D, Ginsbach Philip, Kleinheinz Kortine, Hutter Barbara, Braun Delia M, Cortés-Ciriano Isidro, Xi Ruibin, Kabbe Rolf, Park Peter J, Eils Roland, Schlesner Matthias, Brors Benedikt, Rippe Karsten, Jones David T W, Feuerbach Lars

Abstract excerpt

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32024817
DOI: 10.1038/s41467-019-13824-9
PMCID: PMC7002710

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