Article

Cell cycle alterations associate with a redistribution of mutation rates across chromosomal domains in human cancers

2022-10-25

Abstract excerpt

Somatic mutations in human cells have a highly heterogeneous genomic distribution, with increased burden in late-replication time (RT), heterochromatic domains of chromosomes. This regional mutation density (RMD) landscape is known to vary between cancer types, in association with tissue-specific RT or chromatin organization. Here, we hypothesized that regional mutation rates additionally vary between individual t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22797efd-e40a-52f4-93c8-0ddd627f3423
DOI: 10.1101/2022.10.24.513586

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell cycle alterations associate with a redistribution of mutation rates across chromosomal domains in human cancersDOI 10.1101/2022.10.24.513586Read

Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers.Semantic proximity Read

Chromatin accessibility of primary human cancers ties regional mutational processes with tissues of originSemantic proximity Read

Multifactorial heterogeneity of the human mutation landscape related to DNA replication dynamicsSemantic proximity Read

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.Semantic proximity Read

Chromatin accessibility of primary human cancers ties regional mutational processes and signatures with tissues of origin.Semantic proximity Read

Topography of mutational signatures in human cancer.Semantic proximity Read

Complex correlations: replication timing and mutational landscapes during cancer and genome evolution.Semantic proximity Read

Large tandem duplications in cancer result from transcription and DNA replication collisionsSemantic proximity Read

Topography of mutational signatures in human cancerSemantic proximity Read

Replicative Instability Drives Cancer ProgressionSemantic proximity Read

Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.Semantic proximity Read

Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylationSemantic proximity Read