Topography of mutational signatures in human cancer.

Abstract excerpt

The somatic mutations found in a cancer genome are imprinted by different mutational processes. Each process exhibits a characteristic mutational signature, which can be affected by the genome architecture. However, the interplay between mutational signatures and topographical genomic features has not been extensively explored. Here, we integrate mutations from 5,120 whole-genome-sequenced tumors from 40 cancer...

Topics

• Humans
• Mutation
• Neoplasms
• Genomics
• Base Sequence
• Genome, Human