Article

Chromatin accessibility of primary human cancers ties regional mutational processes with tissues of origin

2021-05-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Regional distribution of somatic mutations in cancer genomes associates with DNA replication timing (RT) and chromatin accessibility (CA), however normal tissues and cell lines have contributed these insights while associations with the epigenomes of primary cancers remain uncharacterized. <h4>Results</h4> Here we model megabase-scale mutation burden in whole cancer genomes...

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Literature Corpus work: 2efe76dd-39da-51e3-9cb2-36b2dbb78819
DOI: 10.1101/2021.05.14.444202

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