Article

Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation

2023-09-28

Abstract excerpt

Local mutation rates are highly heterogeneous across the human genome. This variability was better studied at the scale of megabase-sized chromosomal domains on the one extreme, and at the scale of oligonucleotides at the other extreme. The intermediate, kilobase-scale heterogeneity in mutation risk was less studied. Here, by analyzing thousands of somatic genomes, we considered the hypothesis there are mutation r...

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Literature Corpus work: 6ed4d666-bac1-52ea-a943-7af72d449a06
DOI: 10.1101/2023.09.26.559585

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