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Cellular Senescence in Brain Aging

25 Feb 2021

Abstract excerpt

Aging of the brain can manifest itself as a memory and cognitive decline, which has been shown to frequently coincide with changes in the structural plasticity of dendritic spines. Decreased number and maturity of spines in aged animals and humans, together with changes in synaptic transmission, may reflect aberrant neuronal plasticity directly associated with impaired brain functions. In extreme, a...

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PMID: 33732142
DOI: 10.3389/fnagi.2021.646924

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