Article

Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

2025-04-17

Abstract excerpt

<h4>Summary</h4> Recent 3D analyses reported abundant, small beta-cell-rich endocrine objects (EOs) in the human pancreas. Here, we assessed morphological parameters of >262,000 EOs in pancreas sections from 220 donors with or without type 1 diabetes (T1D), ranging in age and disease duration. We observe many insulin (Ins)+/glucagon (Gluc)-EOs in donors without diabetes. Their relative contribution to the total e...

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Literature Corpus work: 223ae5b5-48f3-51e1-8eed-788f1d52e8bd
DOI: 10.1101/2025.04.11.648319

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