Article

Characterization of the endocrine pancreas in Type 1 Diabetes: islet size is maintained but islet number is markedly reduced

2018-11-29

Abstract excerpt

Insulin deficiency in type 1 diabetes (T1D) is generally considered a consequence of specific beta-cell loss. Since healthy pancreatic islets consist of ~65% beta cells, this would lead to reduced islet size if the beta cells are not replaced by other cells or tissue. The number of islets per pancreas volume (islet density) would not be affected. In this study, we compared the islet density, size, and size distrib...

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Literature Corpus work: becf9412-4067-5d11-a0a3-77e3fa8f6ab8
DOI: 10.1101/480509

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