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Comprehensive Characterization of Islet Remodeling in Development and in Diabetes Using Mass Cytometry

26 Jul 2024

Abstract excerpt

The pancreatic islet is the functional and structural unit of the pancreatic endocrine portion. Islet remodeling occurs in both normal development and pathogenesis of type 1 (T1D) and type 2 diabetes (T2D). However, accurately quantifying changes in islet cellular makeup and hormone expressions poses significant challenges due to large intra- and inter-donor heterogeneity and the limited scalability of...

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PMID: 39058908
DOI: 10.1210/endocr/bqae094

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