Article

Adherent reformed islets: a long-term primary cell-based platform for exploring mouse and human islet biology

2023-11-22

Abstract excerpt

Pancreatic islets are 3-dimensional micro-organs that maintain β-cell functionality via cell-cell and cell-matrix communication. Isolated primary islets are the gold standard for in vitro models. However, native islets present experimental challenges for long-term mechanistic studies owing to their short culture life (approximately 1 week). We developed a novel long-term protocol to study the function of primary i...

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Literature Corpus work: 80fd7a71-ccf6-571b-abd4-cbf9abe06679
DOI: 10.1101/2023.11.22.568245

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