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Interrogating islets in health and disease with single-cell technologies

5 May 2017

Abstract excerpt

BACKGROUND: Blood glucose levels are tightly controlled by the coordinated actions of hormone-producing endocrine cells that reside in pancreatic islets. Islet cell malfunction underlies diabetes development and progression. Due to the cellular heterogeneity within islets, it has been challenging to uncover how specific islet cells contribute to glucose homeostasis and diabetes pathogenesis. Recent advances in...

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PMID: 28951823
DOI: 10.1016/j.molmet.2017.04.012

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