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Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes

26 Feb 2025

Abstract excerpt

AIMS/HYPOTHESIS: The organisation and cellular architecture of islets of Langerhans are critical to the physiological regulation of hormone secretion but it is debated whether human islets adhere to the characteristic mantle-core (M-C) structure seen in rodents. It is also unclear whether inherent architectural changes contribute to islet dysfunction in type 1 diabetes, aside from the loss of beta cells....

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PMID: 40011232
DOI: 10.1007/s00125-025-06376-9

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