Article
Spatiotemporal transcriptome atlas of human embryos after gastrulation.
Nature - 1 Jun 2026
Pan Jiexue, Li Yuejiao, Lin Zhongliang, Lan Qing, Zhang Ying, Chen Huixi, Sui Shengwei, Zhai Man, Zhang Gaochen, Cheng Yi, Tang Yunhui, Wang Qingchen, Xu Yue, Li Guoling, Xu Chunyan, Yan Haoqi, Mao Yiting, Wang Xingxia, Li Hao, Zhu Yiping, Chen Qinfang, Guan Yichun, Meng Nan, Wang Chang, Lu Haiqian, Li Xiangjuan, Zheng Tingting, Yao Xiaoying, Yang Tingyu, Chen Xuan, Qin Qiuyu, Jiang Bin, Ren Yuxing, Liu Xinmei, Zhang Yuxin, Yu Minghui, Wang Lifang, Wei Yanrong, Luo Meiqi, Nancuo Ji, Ma Fuhe, Wang Ziwei, Ou Zhihua, Lei Ying, Jin Xin, Sheng Jianzhong, Xu Congjian, Wu Yanting, Xu Chenming, Zhao Lijian, Yang Hongbo, Gao Ya, Ding Guolian, Xu Xun, Huang Hefeng
Abstract excerpt
The comprehensive spatiotemporal atlas of gene expression during early human embryonic development is critical for insights into embryogenesis1, organogenesis2 and disease origins3,4. Here, leveraging Stereo-seq technology, we generated spatial transcriptomic profiles across 77 sagittal sections of 13 whole-human embryos ranging from Carnegie stage 12 to 23, integrated with single-nucleus RNA sequencing to...
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