Article

Immune and stromal features of durable complete response to radiation and dual immune checkpoint blockade in pancreatic cancer

2026-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Microsatellite stable (MSS) pancreatic ductal adenocarcinoma (PDAC) is refractory to immune checkpoint blockade. We conducted a single-arm phase II trial ( NCT04361162 ) combining nivolumab, ipilimumab and radiation therapy to treat patients with pre-treated metastatic MSS PDAC (n=30). We integrated longitudinal profiling of 32 pre- and on-treatment tumor biopsies from 22 patients, yielding 245...

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Literature Corpus work: 22044b4f-bd20-5b58-9d7e-09654cb1515c
DOI: 10.64898/2026.08.06.26359422

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