Back to search

Article

Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-Seq

2025-01-15

Abstract excerpt

One of the aggressive and lethal cancers, Pancreatic ductal adenocarcinoma (PDAC) is characterised by poor prognosis and resistance to conventional treatments. Moreover, tumor immune microenvironment (TIME) plays a crucial role in the progression and therapeutic resistance of PDAC. It is associated with T-cells exhaustion, leading to the progressive loss of T-cell functions with impaired ability to kill tumor cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2ed66650-69ea-575c-9b7a-93444ece323d
DOI
10.1101/2025.01.13.632574
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Novel Insights into T-Cell Exhaustion and Cancer Biomarkers in PDAC Using ScRNA-SeqDOI 10.1101/2025.01.13.632574
Comprehensive Genomic Analysis of the Prognostic and Immunological Characteristics of Tertiary Lymphoid structures and CD8+ T-cells in Pancreatic Ductal AdenocarcinomaSemantic proximity
Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDACSemantic proximity
Identification and Validation of T Cell Exhaustion Signature for Predicting Prognosis and Immune Response in Pancreatic Cancer by Integrated Analysis of Single-Cell and Bulk RNA Sequencing DataSemantic proximity
Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal AdenocarcinomaSemantic proximity
Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancerSemantic proximity
Single-cell Transcriptomic Profiling of Pancreatic Ductal Adenocarcinoma: Epithelial Reprogramming and Systemic Immune ExhaustionSemantic proximity
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progressionSemantic proximity
Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysisSemantic proximity
Single-cell and spatially resolved atlas of pancreatic cancer reveals immunophenotypes associated with clinical outcomeSemantic proximity
Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencingSemantic proximity
Development and validation of prognostic and diagnostic model for pancreatic ductal adenocarcinoma based on scRNA-seq and bulk-seq datasetsSemantic proximity
Construction of immune related prognostic model for pancreatic ductal adenocarcinoma based on single cell RNA-seq analysisSemantic proximity
Select a neighboring publication to make it the new centre.