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Article

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.

Cancer immunology research - 1 Nov 2017

Stromnes Ingunn M, Hulbert Ayaka, Pierce Robert H, Greenberg Philip D, Hingorani Sunil R

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to most therapies, including immune checkpoint blockade. To elucidate mechanisms of immunotherapy resistance, we assessed immune parameters in resected human PDA. We demonstrate significant interpatient variability in T-cell number, localization, and phenotype. CD8+ T cells, Foxp3+ regulatory T cells, and PD-1+ and PD-L1+ cells were...

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Identifiers

PMID: 29066497
DOI: 10.1158/2326-6066.CIR-16-0322
PMCID: PMC5802342

Genes

FOXP3

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