The role of enhancers in cancer.

doi:10.1038/nrc.2016.62

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Article

The role of enhancers in cancer.

Nature reviews. Cancer - 1 Aug 2016

Sur Inderpreet, Taipale Jussi

Abstract excerpt

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control the signal-dependent expression of growth-related genes. This...

Topics

Enhancer Elements, Genetic
Epigenesis, Genetic
Female
Genetic Predisposition to Disease
Humans
Male
Neoplasms

Source

Open in PubMed

Identifiers

PMID: 27364481
DOI: 10.1038/nrc.2016.62

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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